Pharmacology assignment Example | Topics and Well Written Essays - 2500 words - 1

Pharmacology - Assignment Example Healthy participants will be assigned to group A and B. subjects in group A were given 50mg of JP234 from day 3 to day 10 and warfarin 1.5 mg from day 7 to day 14. Participants in group 2 will receive 1.5 mgs of warfarin from day 3 to 10 and then 50mgs once a day from day 7 to 14. Both drugs will be administered for the first fourteen days while the remaining six days will be utilized as washout period. Plasma levels of the drugs will be assessed in both groups. Monitoring the plasma concentration is essential in drug interaction studies. The subjects will be closely monitored for heart activity, clotting factor level and heart rate through utilization of an electrocardiogram. The drug is believed to be well tolerated during clinical trials and has less contraindication association with it (Simon, 2007). The result of the finding will be utilized in identifying the action of the new drug on the metabolism of warfarin. Through blood sample study and the hearts activity measure, the ef fectiveness and the action of JP234 on warfarin will be measured. The study aims at finding out the effect of JP234 on the action of warfarin. Any changes on the participants will be recorded. Tolerability and the safety of the drug will be assessed too. JP234 is well tolerated during clinical trials and there is no contradiction associated with it. The drug when administered is effective in doses of 50, 75 or 100mg once daily. The drug is metabolized in the liver and has a half life of about 24 hours. In vitro studies indicate that the drug can induce CYP2C9. Patients with chronic atrial fibrillation should be anticoagulated to hinder thromboembolism from taking place (Goodman, 2005). Patient taking JP234 are recommended to take warfarin that is partly metabolized by CYP2C9. JP234 is an antiarrhythmic drug and is usually excreted in the liver just the same as warfarin. The new drug is considered an inducer of CYP2C9 which takes

Impacts of Emotional Intelligence of leaders on job satisfaction and Essay

Impacts of Emotional Intelligence of leaders on job satisfaction and Turnover Intentions of followers 02141 - Essay Example Job satisfaction among its employees has been a fundamental reason of the turnover problem as research conducted by Brunetto et al. (2012) suggests. Conversely, whenever an organisation is committed to emotional intelligence, it becomes easier for its employees to be motivated. In fact, Trivellas et al (2013) found that organisational commitment determines the satisfaction of the staff, hence influencing the turnover intentions. In light of these facts, it is highly recommendable that a research be conducted to find a way to mitigate the situation. Therefore, this research intends to analyse the impact the emotional intelligence of leaders has on job satisfaction and subsequent turnover intentions on followers. Credible statistics have proved that Job Satisfaction (JS), Emotional Intelligence (IE) and Turnover Intentions (TI) are firmly intertwined. In essence, it means that none of it can be overlooked or given more attention that the other (Ganzach and Fried, 2012). Unfortunately, this is not something that many business owners have noticed, but rather they tend to focus on the TI without a decisive action to investigate the root problem (Siddique, 2014). Consequently, this approach has proved to be a dilemma for many business owners. For this reason, it would a grievous mistake not to identify these issues and deal with them conclusively. Corporate play an important role in creating employment thus any issue that could prove to be a hurdle ought to be assessed and dealt with early. The proposal will highlight the underlying issues in the three aforementioned areas. In addition, it will offer the concerned parties an opportunity to find a solution in a bid to continue guaranteeing profitability, which is possible through maintenance of a motivated, satisfied workforce. As stated above, the research seeks to understand and bring into the limelight the issues that influence JS